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QuinXell’s novel TisXell Regeneration System (Biaxial Bioreactor) is designed specially for Tissue Engineering and Regenerative Medicine. It offers a favourable environment for high growth and high proliferation of 3D cell cultures compared to conventional methods.  The biaxial bioreactor controlled environment provides optimal nutrients and gases to growing cells and triggers cellular mechano-transduction signaling pathways to stimulate remodeling onto a 3D scaffold.

  • Our integrated solution addresses a broad range of tissue engineering processes and cell culture applications including that of single cells on microcarriers and slow-growing cell types with unsurpassed cell quality. Spherical design of vessel reduces drag and promotes uniform fluid mixing.

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      Unique Features

    • Patented biaxial revolution on two independent axes in multiple directions simultaneously
    • Flexible operational modes available – biaxial, uniaxial, swing modes
    • Efficient fluid transport within the 3D scaffolds, allowing optimal nutrients and waste exchange to and from the cells, penetrating the deepest core of the scaffolds
    • Spherical design of vessel remove flow “dead legs” and promotes uniform laminar flow

     

     

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      Customised Solutions

    • Tailor-made solutions are available upon request. Please contact your local office.

     

     

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      Key Benefits

    • Accelerates cell growth, differentiation and cell proliferation, mimicking native extracellular matrix (ECM)
    • Supports homogenous cell culture at the surface and core of the 3D scaffolds
    • Maintains functionality and viability of tissue constructs
    • Reduces formation of necrotic neo-tissue that interferes with subsequent implantation process
    • Promotes integration of implants with surrounding tissue and support the structural integrity in regeneration of tissues and organs
  • TisXell Regeneration System

    TisXell Regeneration System

    Patented Innovative Design

    • Independently-controlled drive axes for biaxial, single axis and swing modes for arm rotation of 1 to 12rpm, and chamber rotation of 1 to 35rpm. Direction of rotation is selectable
    • Continuous perfusion with integrated variable speed peristaltic pump providing flow rates from 3 to 500ml/min
    • Oxygenator column unit to facilitate gaseous exchange
    • Medium reservoir acting as a sensor bank with ports for optional temperature, pH, and oxygen probes
    • Heat-isolated console for system drivers and controller

     

    Arm Assembly with Sensors

    • Weight-balanced rotary arm for 50ml, 500ml and 1000ml spherical culture chambers
    • Built-in sensors to detect arm angle and positions for fully programmable operations
    • With tubing gripper and rotator mounts
    Control-Panel

    Remote Touch Screen Controller

     

     

    500ml and 1000ml culture chambers are available as standard configuration. 50ml culture chamber allows for dynamic seeding with “cell concentrator”. Dual stacker permits simultaneous operation of two 50ml chambers in continuous perfusion.

    500ml and 1000ml culture chambers are available as standard configuration. 50ml culture chamber allows for dynamic seeding with “cell concentrator”. Dual stacker permits simultaneous operation of two 50ml chambers in continuous perfusion.

     

     

    Modular Culture Chambers & Accessories

    • 500ml and 1000ml uniquely spherical culture chambers with detachable base and chamber stand
    • Clear, transparent culture chamber with 360 degrees view
    • With dual containment fluid sealed cap and sterile rotators
    • Accessories include various scaffold holders and rotating core

     

    Highly Versatile Operation Modes

    • Selectable biaxial, uniaxial and swing modes of operation
    • Programmable speeds, directions and swing angles including cycle-track feature
    • Intuitive touchscreen remote panel with interactive user interface for complete management of system while unit is inside a laminar fow hood or a CO2 incubator
    TisXell in a CO2 incubator

    TisXell in a CO2 incubator

  • For research institutes, hospitals, biotechnology and pharmaceutical companies in:

    • Bone Regeneration
    • Biomaterial Testing
    • Cell Co-Cultures
    • Cartilage Regeneration
    • Heart Patch Research
    • Stem Cell Expansion

    For Bone Cells

    Enhanced Cell Proliferation and Viability

    Conventional

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    TisXell

    tixsell

    Increased necrosis in conventional culture conditions after 28 days

    Increased Osteogenic Properties

    Conventional

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    TisXell

    tixcell

    3 months after tissue engineered bone graft


    Intensified Vascular Ingrowth in Rat Femur

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    Stem Cells Grown on Microcarriers

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